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Wednesday, April 29, 2020 | History

2 edition of The Canine as a biomedical research model found in the catalog.

The Canine as a biomedical research model

The Canine as a biomedical research model

Immunological, hematological, and oncological aspects

by

  • 352 Want to read
  • 15 Currently reading

Published by available from National Information Service, U.S. Dept. of Commerce .
Written in English

    Subjects:
  • Dog diseases,
  • Dogs as laboratory animals,
  • Disease models, Animals,
  • Dogs,
  • Medicine,
  • Diseases,
  • Research,
  • Animal models,
  • Animals, Laboratory

  • The Physical Object
    FormatPaperback
    Number of Pages425
    ID Numbers
    Open LibraryOL8345282M
    ISBN 100870791222
    ISBN 109780870791222
    OCLC/WorldCa6816003

    For animal research that causes sentient nonhuman animal suffering to be justifiable, I believe that two conditions must be met. First, harming animals for human benefit must be morally justified; this is the speciesism justification. Second, animal research must have utility—that is, it must produce useful, empirically valid knowledge that successfully increases our understanding of human.   She found a calling in nutrition and research and returned to Virginia-Maryland to complete a PhD in Biomedical and Veterinary Sciences along with a comparative nutrition residency. Dr. Shepherd is a diplomate of the American College of Veterinary Nutrition and has been a faculty member as a Clinical Assistant Professor at Virginia-Maryland. He currently serves on the Research Review Committee of the Saint Louis Zoo. Previously, he served on the IACUC of Lehman College () and the National Zoo, Rock Creek Campus (). David’s research has focused on a number of species and topics over the years in zoos and in the field. The. National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare.


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The Canine as a biomedical research model Download PDF EPUB FB2

The Canine as a biomedical research model: Immunological, hematological, and oncological aspects [Moshe Ph.D.;United States;Wi lson, Floyd The Canine as a biomedical research model book.

Shifrine] on. Heather Finlay, in Annual Reports in Medicinal Chemistry, I KAch Inhibitors. The potent and selective I KAch inhibitor NTC(4; Fig. ) demonstrated significant increases in AERP and AF termination efficacy in the The Canine as a biomedical research model book vagal nerve stimulated canine model in addition to reduced AF inducibility in the dual paced canine model.

26 NTC advanced to a Phase II study in the. Get this from a library. The Canine as a biomedical research model: immunological, hematological, and oncological aspects. [Moshe Shifrine; Floyd D Wilson; United States. Department The Canine as a biomedical research model book Energy.

Office of Health and Environmental Research.;]. The 2e of the gold standard text in the field, Nonhuman Primates in Biomedical Research provides a comprehensive, up-to-date review of the use of nonhuman primates in biomedical research. The Biology and Management volume provides basic information on the natural biology of nonhuman primates and the current state of knowledge regarding captive management.

The Common Marmoset in Captivity and Biomedical Research is the first The Canine as a biomedical research model book dedicated exclusively to this species,filling an urgent need for an encyclopedic compilation of the existing red by the American College of Laboratory Animal Medicine as part of its authoritative Blue Book series, the book covers the biology,management, diseases, and clinical and research applications.

The Laboratory Canine clearly presents basic background information covering subjects that apply specifically to dogs used in research settings, such as basic biological features, husbandry, management, veterinary care, experimental methodology, and resources.

The book offers guidance on performing a detailed physical examination, including Format: Hardcover. Animal models still play a crucial role in biomedical research.

Among them, The Canine as a biomedical research model book canine and feline tumors could be useful to accelerate the entry of new effective drugs into clinical practice.

Related Posts. Avian Virology: Current Research and Future Trends Ap The Buffalo (Bubalus bubalis): Production and Research Janu ; Laboratory Animals: Regulations and Recommendations for the Care and Use of Animals in Research, 2nd Edition Janu Canine Medicine: Recent Topics and Advanced Research Janu ; Nonhuman Primates in.

Dogs are rarely cured by chemotherapies used for The Canine as a biomedical research model book, “so trying new immunotherapies in newly diagnosed patients is a win-win situation,” potentially curing those dogs of their lymphomas while rapidly advancing research, Richards said.

For years mice have been the main animal model used for research on human diseases. The Sourcebook of Models for Biomedical Research is a comprehensive and extensive collection of these important medical parallels.

While the entire book is not devoted to the remarkable success of the genomic programs, this work is well represented and indexed within these pages. Madin-Darby Canine Kidney (MDCK) cells are a model mammalian cell line used in biomedical research. MDCK cells are used for a wide variety of cell biology studies including cell polarity, cell-cell adhesions (termed adherens junctions), collective cell motility, as well as responses to growth is one of few cell culture models that is suited for 3D cell culture and multicellular.

Canine Diabetes Mellitus Study Dr. Allison O’Kell examines Finn, a 4-year-old, healthy black Lab, before drawing a blood sample for a canine diabetes study she is leading. The University of Florida College of Veterinary Medicine is currently recruiting dogs with diabetes for a clinical research study.

Background: Large animal models, such as the dog, are increasingly being used for studying diseases including gastrointestinal (GI) disorders. Dogs share similar environmental, genomic, anatomical, and intestinal physiologic features with humans. To bridge the gap between commonly used animal models, such as rodents, and humans, and expand the translational potential of the dog model, we Cited by: 4.

In addition to the value of canine TCC as a genetic model, the disease also serves as a therapeutic model. The cyclooxygenase inhibitor piroxicam has been studied in canine drug trials for the treatment of TCC.

One study showed a complete remission in two dogs and a partial remission in four out of 34 dogs (Knapp et al., ).Cited by: Biomedical Laboratory Research and Development. Biomedical Laboratory Research and Development (BLRD) supports and conducts preclinical research to understand life processes from the molecular, genomic, and physiological levels for the purpose of advancing science and the understanding of how diseases affect Veterans.

The collection of systems represented in the Sourcebook of Models for Biomedical Research reflect the diversity and utility of models that are used in biomedicine. The report identified various factors which contributed to creating an unfulfilled need for veterinarians in the biomedical research workforce, including an increase in the number of NIH grants utilizing animals and the burgeoning use of transgenic rodents, without a comparable change in the supply of appropriately-trained veterinarians.

F.J. Dowd, in Reference Module in Biomedical Sciences, Animal Models. A dog model is used to test electrophysiological aspects of heart block (atrioventricular block) (van-Opstal et al., ).Chronic complete heart block in dogs has been shown to lead to myocardial hypertrophy and polymorphic ventricular tachycardia (Schreiner et al., ).A porcine model for complete heart block has.

For many scientific experiments, the answer to those questions will be the domestic dog, Canis familiaris. The size, biologic features, and cooperative, docile nature of the well-socialized dog make it the model of choice for a variety of scientific inquiries. The contributions of the dog to human health and well-being are numerous (Gay, ).

The research community has attempted to push back against these trends through national science advocacy groups such as the FBR, the National Association for Biomedical Research (NABR 15), and Americans for Medical Progress (AMP 16), all of which work to educate the public about the importance of animals in research.

Project Scope: I n response to a request from the U.S. Department of Veterans Affairs (VA), the National Academies of Sciences, Engineering, and Medicine will appoint an ad hoc committee to review the care and use of dogs in biomedical research funded by the VA or carried out in VA facilities regardless of funding source, for the purpose of advancing science and the understanding of how.

The bovine castration model is a silicone model consisting of reusable testicles and disposable testicular cords and scrotum. The model is used for 3 rd year students to learn this skill prior to performing it during their clinical year of veterinary school.

The model can be used to teach surgical and non-surgical castration methods such as. 26 Swine in Biomedical Research M. Michael Swindle and Alison C.

Smith 27 The Minipig as an Animal Model in Biomedical Stem Cell Research Petr Vodicka, Jana Hlucilova, Jiri Klima, Radek Prochazka, Jitka Ourednik, Vaclav Ourednik, and Jan Motlik D NONHUMAN PRIMATES 28 The Nonhuman Primate as a Model for Biomedical Research David M.

Textbooks, article, and proceedings detailing a large number of models and technical procedures for using swine in the laboratory are available. 21,47,50,52,53 There is a large body of literature covering the normal anatomy and physiology of the species, and pathology descriptions related to infectious or degenerative diseases in swine under Cited by: The Baboon in Biomedical Research.

by Sarah Williams-Blangero, Suzette D. Tardif, John L. VandeBerg November Building on the foundation of two earlier volumes, The Baboon in Biomedical Research returns in an updated edition that presents the variety of uses and the importance of the baboon in biomedical research today.

Abstract. Animal models still play a crucial role in biomedical research. Among them, spontaneous canine and feline tumors could be useful to accelerate the entry of new effective drugs into clinical by: 3.

20 institutes and centres) sponsored research that supported separate grants that uti-lized the pig. Thus, a broad foundation sup-porting the pig as a model in biomedical research already exists from which to build future programmes. There is also growing Pigs as a Model 17 for Biomedical SciencesFile Size: KB.

The Foundation for Biomedical Research (FBR) is an American non profit organization, (c)(3), located in Washington, ished inthe organization is dedicated to informing the news media, teachers, and other groups about the need for lab animals in medical and scientific research.

Virtual Canine Anatomy enhances the students’ dissection experience and helps them learn anatomy efficiently (Linton, Schoenfeld-Tacher, Whalen, ). The program allows the luxury of self-paced, individualized learning and provides a focal point around which the instructor and student can exchange ideas and make interpretations of course.

Identifying appropriate animal models is critical in developing translatable in vitro and in vivo systems for therapeutic development and investigating disease pathophysiology. These animal models should have direct biological and translational relevance to the underlying disease they are supposed to mimic.

Aging dogs naturally develop a cognitive decline in many aspects including learning and Cited by: 1. Cancers such as bone cancer, lymphoma, and bladder cancer spontaneously arise in dogs, due to the same genetic mutations that causes cancer in humans.

Pioneering treatments, like immunotherapy, can be used to treat canine cancer, laying a foundation for human clinical trials. Comparative oncology centers conduct trials in dogs with cancer to evaluate new treatments for dogs. Chapter 1 Canine Olfaction: Scent, Sign, and Situation Simon Gadbois and Catherine Reeve Abstract Canine olfaction is a rich field of study for the behavioural sciences and neurosciences, and it is rich in interdisciplinary connections.

This chapter will explore the neurocognitive and neuroconative bases of olfaction (the neurophysi-Cited by: • Biomedical research of heart disease – For example, at Ohio State University, dogs were forced to run on a treadmill until they collapsed from a heart attack.

If they were not dead upon falling, the dogs were killed so that the damage to their heart tissue could be studied. The great increase in the study of dog cognition in the current century has yielded insights into canine cognition in a variety of domains.

In this review, we seek to place our enhanced understanding of canine cognition into context. We argue that in order to assess dog cognition, we need to regard dogs from three different perspectives: phylogenetically, as carnivoran and specifically a Cited by: 4.

The Committee on Scientific and Humane Issues in the Use of Random Source Dogs and Cats in Research was assigned three specific tasks. The first task required an analysis of the available data to determine the important biomedical research questions and common research topics in contemporary NIH-funded research where dogs and cats from Class B dealers are desirable or necessary as well as.

Canine Ergonomics: The Science of Working Dogs draws together related research from different fields into an interdisciplinary resource of science-based information.

Providing a complete overview, from physiology to cognition, this is the first book to discuss working dogs from a scientific perspective.

Dogs References and resources for this tutorial. Robert C. Dysko, et. al., "The Biology and Diseases of Dogs," Chapter 11 in Laboratory Animal Medicine, 2 nd Edition, James G. Fox, et. al., editors (New York: Academic Press, ). Laboratory Animal Management: Dogs (online book from National Academy Press, ).

Chapter 28 in The UFAW Handbook on the Care and Management of Laboratory. “This book covers canine and feline dementia, spanning topics from clinical signs and differential diagnoses to the use of dogs as a natural model for Alzheimer's disease.

It provides university teachers and scientists with a review of the most up-to-date research on canine and feline dementia while highlighting areas of future research. In lieu of an abstract, here is a brief excerpt of the content. CANINE PAIN SYNDROME IS A MODEL FOR THE STUDY OF KAWASAKI DISEASE JANE C.

BURNS* PETERJ. FELSBURG,t HARRY WILSONj FRED S. ROSEN,§ and LAWRENCE T. GLICKMANt Kawasaki disease (KD) is an acute, self-limited vasculitis of unknown cause that affects infants and young children [I]. The canine is another commonly used model in biomedical device research.

Information on atrial-to-ventricular timing in canines was published by Karpawich et al. (15). They placed tripolar electrodes on the right atrial epicardium near the noncoronary cusp of the aorta of canines; the resulting timing recorded was extracted from the article and.

Since the great Rudolf Virchow advised, “Between animal and human medicine there is no dividing line, nor pdf there be,” limited attention pdf been paid to cancer in animals. This is finally changing thanks to a renewed focus on studying pet dogs with cancer. Unlike the laboratory mice who have been the mainstay of animal models of disease, pet dogs share an environment with their human Author: Alexander L.

Lazarides, Allison B. Putterman, William C. Eward, Cindy Eward. Physician-Scientist Workforce (PSW) Report ACD Biomedical Workforce Working Group Data Investigators and Trainees Data Book: The NIH-Funded Research Workforce Data Book: NIH Research Training Grants and Fellowships Data Book: Research Career Development Awards.Research Institute, 5 College of Pharmacy, ebook Mass Spectrometry and Proteomics Facility, The Ohio State Ebook, Columbus, OH 7 Department of Pathology, Microbiology, and Immunology, University of California, Davis, CA MCB – 2 BIOLOGIC ACTIVITY OF THE NOVEL SMALL MOLECULE STAT3 INHIBITOR AGAINST CANINE OSTEOSARCOMA CELL LINES J.

Couto 1, M.